Loop Diuretics in Clinical Practice
نویسندگان
چکیده
منابع مشابه
Loop Diuretics in Clinical Practice
Diuretics are commonly used to control edema across various clinical fields. Diuretics inhibit sodium reabsorption in specific renal tubules, resulting in increased urinary sodium and water excretion. Loop diuretics are the most potent diuretics. In this article, we review five important aspects of loop diuretics, in particular furosemide, which must be considered when prescribing this medicine...
متن کاملHow do loop diuretics act?
In the thick ascending limb of the loop of Henle, NaCl reabsorption is mediated by a Na+/2Cl-/K+ cotransport system, present in the luminal membrane of this nephron segment. Loop diuretics such as furosemide (frusemide), piretanide, bumetanide and torasemide bind reversibly to this carrier protein, thus reducing or abolishing NaCl reabsorption. This leads to a decrease in interstitial hypertoni...
متن کاملVascular effects of loop diuretics.
Although it is generally believed that the beneficial effect of loop diuretics is the result of a rapid increase in diuresis, substantial evidence, from a large number of in vitro and in vivo experiments, has accumulated showing that administration of furosemide causes direct vascular effects, which probably contribute to its acute clinical effects. Several mechanisms are involved in the vascul...
متن کاملResponsiveness to loop diuretics in heart failure.
Loop diuretics are the most commonly used drugs in the management of pulmonary and systemic congestion in patients with acute decompensated heart failure (ADHF), as well as chronic congestive HF. The diuresis results from blockade of the Na+–K+–Cl2 co-transporter in the ascending limb of the loop of Henle. The pharmacodynamics of loop diuretics are illustrated in Figure 1, and are best describe...
متن کاملClinical use of diuretics
on therapy in renal disease. Arch Intern Med 1981;141:1039–41. 4 Turner MW, Hutchinson TA, Barre PE, Richard S, Jothy S. A prospective study on the impact of the renal biopsy in clinical management. Clin Nephrol 1986;26:217–21. 5 Cohen AH, Nast CC, Adler SG, Kopple JD. Clinical utility of kidney biopsies in the diagnosis and management of renal disease. Am J Nephrol 1989;9:309–15. 6 Farrington ...
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ژورنال
عنوان ژورنال: Electrolytes & Blood Pressure
سال: 2015
ISSN: 1738-5997,2092-9935
DOI: 10.5049/ebp.2015.13.1.17